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Glutathione - your brains master antioxidant apology - supplements


Free radicals and oxyradicals play an central role in the change and development of many brain disorders such as brain injury, neurodegenerative disease, schizophrenia and Down syndrome.

Glutathione is the brain's master antioxidant and plays an chief defending role in the brain.

According to Dr. Jimmy Gutman, "The brain is acutely susceptible to free radical assail for the reason that it generates more oxidative by-products per gram of bandanna than any other organ. "

Many neurological and psychiatric disease processes are characterized by. . . abnormalities in glutathione metabolism and antioxidant defenses. "

Generation of immediate oxygen species (free radicals) and oxidative destruction are an chief cause of neuron (brain cell) death from brain injury.

Chemicals that cause toxicity to a number of brain cells are known to decline analytical glutathione (GSH), construction the cells more vulnerable to immediate oxygen species (ROS). (1)

On the other hand, over-expression of the glutathione peroxidase (GPX) enzyme potently decreases cell death from brain injury. (2)

Brain Injury and Glutathione - The Gender Difference

Researchers at Children's Infirmary of Pittsburgh have found that males and females answer back in a different way to brain injury. (3)

In bodily models, levels of glutathione continue continual in females who have suffered a brain injury, but drop by as much as 80 percent in males with the same injury.

When glutathione levels drop, brain cells die much more quickly. This suggests that boys with brain injuries may call for assorted life-saving treatments than girls.

N-acetyl-cysteine (NAC), a foretaste of glutathione, before now agreed for use by the U. S. Food and Drug Direction to treat associates who have overdosed on acetaminophen, may be an helpful conduct for brain injury in boys whose brains are deprived of oxygen.

Brain Disorders and Glutathione - A Genetic Cause?

Genetics researchers have found that the glutathione S-transferase gene pedals the onset of Alzheimer's, Parkinson's disease and determines, not if we get these diseases, but when. (4)

The glutathione S-transferase gene has earlier been connected to the risk for Parkinson's disease among citizens who used pesticides.

A earlier critique roofed the import of glutathione in Parkinson's Disease.

Alzheimer's Disease and Glutathione

Free radicals and oxidative dent in neurons is known to be a core cause of degenerative diseases like Alzheimer's disease.

Amyloid- peptide (A) accrual in senile plaques, a pathological brand of Alzheimer's disease (AD), has been caught up in neuronal degeneration.

Amyloid plaques encroaching on the brain amplify the fabrication of free radicals, or oxidative stress. Antioxidants, such as vitamin C and E "mop up" the harmful free radicals.

Glutathione (GSH) precursors can check death of brain cells induced by amyloid plaques in Alzhiemer's disease, while substances that drain GSH amplify cell death. (5)

Evidence has been crutch up over the link amid the quantity of an amino acid called homocysteine in the blood and the accidental of emergent Alzheimer's.

For ancestors not genetically disposed to budding Alzheimer's, cholesterol and homocysteine, essentially caused by an unhealthy lifestyle, are the core causal factors.

Welsh GP, Andrew McCaddon, showed that the more homocysteine that patients with Alzheimer's had, the worse their mental performance, and the worse their "cognitive impairment," the less they had of the antioxidant glutathione. (6)

Glutathione and Mood Disorders

Studies have found that the mood stabilizing drug, valproate, used to treat epilepsy and bi-polar disorder, regulates demonstration of the genes that make glutathione-S-transferase (GST).

In addition, continual action with lithium, an added normally prescribed mood additive used in treating manic-depression, also augmented levels of GST.

These findings led researchers to conclude that glutathione S-transferase may be a novel aim for mood stabilizing drugs. (7)

Alcohol Expenditure and Glutathione

Alcohol abuse is known to impair recall and other brain functions and become more intense brain cell death. A new study in rats has shown that alchol expenditure causes fewer new brain cells to form and fallout in bigger cell death. (8)

But rats that were fed alcohol along with Ebselen - a glutathione peroxidase mimic that acts as a free radical searcher - showed no comparable bargain in brain-cell formation and no augment in cell death.

Substances that Boost Glutathione Levels and Keep Brain Cells

Taking glutathione itself as a supplement does not boost cellular glutathione levels, since it breaks down in the digestive tract already it reaches the cells.

However, intravenous glutathione therapy and glutathione precursors or dietetic supplements are actual in boosting intracellular levels of glutathione.

Intravenous Glutathione Injections: Intravenous glutathione injections have been shown to churn out amazing and rapid results, in patients with Parkinson's disease. Next even a distinct amount of intravenous glutathione, many of the symptoms of Parkinson's disease hurriedly improve, often in as hardly as 15 minutes.

Glutathione Precursors: In the Alzheimer's study conducted by Welsh GP, Andrew McCaddon, adding up the glutathione precursor, N-acetyl-cysteine (NAC) to a protocol that lowered homocysteine levels by clean supplementation with B12 and folate, resulted in prompt, striking, and sustained clinical development in all but all the patients. (9)

Cucurmin (turmeric):Studies have shown that the Indian curry spice, cucurmin, has neuroprotective possessions since of its aptitude to induce the enzyme, hemeoxygenase-1 (HO-1), which protects neurons exposed to oxidant stress. Behavior of brain cells called astrocytes, with curcumin, increases appearance of HO-1 protein as well as glutathione S-transferase. (10)

Ebselen: Ebselen is a glutathione peroxidase mimic and forceful fake antioxidant that acts as a neuroprotective agent and an inhibitor of free-radical induced apoptosis (cell death). It can guard brain cells from the neuro-toxic belongings of alcohol consumption. (8)

Undenatured Whey Protein: Undenatured whey protein provides glutathione precursors, has been shown to raise intracellular glutathione levels in clinical trials, and has anecdotally been reported to advance the symptoms of Parkinson's disease.

References: 1. Journal of Neurochemistry, Vol. 88, No. 3, 2004 513-531
2. Journal of Neurochemistry, Vol. 87, No. 6, 2003 1527-1534
3. Researchers Find Brain Cells Die In a different way in Males and Females; Pediatric College Societies Press release; 21-Apr-2004
4. Human Molecular Genetics, 2003, Vol. 12, No. 24 3259-3267
5. The Journal of Cell Biology, Degree 164, Digit 1, 123-131; 5 January 2004
6. Biol Psychiatry. 2003 Feb;53(3):254-60
7. Journal of Neurochemistry, Vol. 88, No. 6, 2004 1477-1484
8. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7919-24. Epub 2003 Jun 05.
9. Am J Geriatr Psychiatry. 2003 Mar-Apr;11(2):246-9
10. Can Curry Care for Anti Alzheimer's?; American Physiological Association (APS) Press Release; 16-Apr-2004

Copyright 2004 Priya Shah

This clause was first available in the May 2004 issue of The Glutathione Report, a newsletter featuring accepted updates on the physical condition remuneration of glutathione. Get a Free account on Glutathione in Shape and Disease


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